Human microbiota consist of many bacteria, viruses, fungi and even parasites which live with us peacefully, keeping us healthy and training our immune system to be active and balanced. Only balanced immunity can face new or opportunistic pathogen with enough power but without creating serious side effects.
Long term isolation and distancing from other human beings, constant disinfection, fear and stress, they all have a negative effect on our little "friends" living in our gut and other mucosal surface of the body.
What else weakens our microbiota?